AFLAGELLARY FORMS OF TRICHOMONAS SPECIES AS ETIOLOGIC AGENS OF CYSTIC FIBROSIS(MUCOVISCIDOSIS)
WOMEN'S HEALTH INSTITUTE,Sarajevo,Yugoslavia
The comparative investigation of phenomenology of human trichomoniasis,chronic nonspecific hypertrophic cervicitis with expressed mucorrhoa,as well as mucus from mothers and their children ill from cystic fibrosis (CF),resulted in conclusion of infective etiology of that children disease,for which it is today claims that it is metabolic disorder with autosomal recessive inheritance.
The frequent genital trichomoniasis and common premature rupture of the membranes diring pregnancy make the infection of the amniotic fluid with microbe possible.This author observed aprox. 15000 cases of trichomonas cervicitis and 11 CF cases with trichomonads in their respiratory tract.
By swallowing infected fluid the fetus infects the intestine and pancreas,which is the classical target organ for the CF process.
The mucus cells after sensitization react by hypersecretion,typical appearence by CF. In case when primary infection happened prepartally the trichomonal
reinfection thereafter causes allergic reactions.The opportunistic infections make more difficult and complicate the clinical and pathoanatomic picture.
The primary infection during and after delivery causes the disease in the respiratory tract. In such case the the catarrhal symptoms (phase of
sensitization) is followed by the appearence of the immune complex in circulation and hypersecretion of mucus ij the respiratory tract.
As the spider wraps the victim by its cobweb,so the mucous cells exert by mucus the chemical, mechanical and immune neutralization and expulsion of parasites.
This suppression results in regressionof trichomonads into the round forms of para- sites and their fatal "mimicry",as they do not differ from leukocytes when coloured by standard methots,which include fixing.All laboratory findings,which may be speci- fic for the CF are consequences of intoxication or/and allergic reactions to the trichomonal toxines, which is also true of the stronger secretion of NaCl in sweat.
Simultaneous action of three factors:(a)frequent family trichomonas infestation, (b)congenital/peripartal infection and/or intoxication of embryo/fetus,as well as (c)autosomal recessive inheritance of susceptibility to infections,results with imitat- ion of genetic inheritance of CF.
By geneticians observed chromosomal changes in CF families could be of immunogenetic nature as response to chronic family trichomonad infection.
Identification of primary focus of infection and then desinfestation lead to the with- drawal of clinical symptoms and by early discovered cases to the restitutio ad integrum of pathoanatomic changes.
Presented in shorted version on VIIIth European Immunology Meeting held in Zagreb Aug-Sept 1987,printed in Meeting Abstract Book of Periodicum Biologorum,Vol.89, Supp 1,p 1-232,Zagreb,July 1987.
In this form presented on XIIth World Congress of Gynecology/Obsterics held in Rio de Janeiro 1988,Oct 23/28,Abstracts pp 681-2.