CROSSREACTION BETWEEN TRICHOMONAS FELIS ANTIGENS AND IMMUNE FORCES AGAINST HUMAN TRICHOMONAS INFECTIONS COULD BE STRONGLY  INVOLVED IN CAT-SCRATCH DISEASE

 Krvavac S. and Krvavac J*.,Gynecologic Service Stari Grad, Apoteke* Sarajevo, 71000 SARAJEVO, Bosnia-Herzegovina.

 Our gynecologic patient aged 49 with chronic cervical Trichomonas(T) infection  and frequent exacerbations was refered to GP because of tumour in fossa poplitea of right knee (3x2x1cm).Tumour was movable, soft and painless.After 7 days antibiotic cure there was no improvement but genital symptoms reappeared because of which she refered to us.

For the first time after many years,we have not found Ts in her cervical mucus by direct microscopy of stained wet smear.We yet prescribed metronidazole rectally,because of  gastric disorders:2 times 0,5 during 5 days.

Genital symptoms disappeared after 3-4 days and 2 weeks later the tumour was not more palpable.In the meantime GP recognized the tumour as lymphadenitis after cat-bite of the right big toe,which happaned 4 weeks before her first visit.

On gynaecologic control 5 months later,she has been already 3 months in menopausis, with parasite-free cervical canal.

Today's knowledge about immunogenic capacity of Ts allows to presume the cross- reaction between T felistome of the cat and immune forces of its owner, earlier infected by any of 3 T sp. inhabiting the man worldwide.The crossimmunity could be caused by common antigens of feline and human Ts, particularly if the related mammal organs of hosts are colonised.

As the structures of T antigens, mostly secreting proteinases,depend on composition of surrounding nutrients,especially on animal proteins,so some parts of antigens can be common in protozoa of the pet and owner.

In our case,the strong immune challenge after cutaneous inoculation of Ts or only antigens,could "spontaneously" clear the cervical infection,particularly as genital mucosal membrane has lost nutritious glycogen during menopausal estrogen fall.

From parasitologic viewpoint,pigmentation around parasite entry and connective tissue hyperplasia on the outskirts of host/pathogen contact,suggest the possible parasite involving.Her age (49) could also be included in the above concept.

Clinico-pathologic and epidemilogical effects of the close cat/man contact,both infected and sensitized with related protozoa should not be underrated,especially because these agents have strong immunoerosive potential and can be the vectors and even protectors of various bacteria and viruses,ingluding HIV,during antibiotic cure.

 
Genito-to-digestive tract T infection transfer could additionaly uniform T antigens in pet and its owner so intensifying the immune crossreaction.

 
Our gynecologic patient aged 49 with chronic cervical Trichomonas(T) infection and frequent exacerbations was refered to GP because of tumour in fossa poplitea of right knee (3x2x1cm).Tumour was movable, soft and painless.After 7 days antibiotic cure there was no improvement but genital symptoms reappeared because of which she refered to us.

For the first time after many years,we have not found Ts in her cervical mucus by direct microscopy of stained wet smear.We yet prescribed metronidazole rectally,because of gastric disorders:2 times 0,5 during 5 days.

Genital symptoms disappeared after 3-4 days and 2 weeks later the tumour was not more palpable.In the meantime GP recognized the tumour as lymphadenitis after cat-bite of the right big toe,which happaned 4 weeks before her first visit.

On gynaecologic control 5 months later,she has been already 3 months in menopausis, with parasite-free cervical canal.


Today's knowledge about immunogenic capacity of Ts allows to presume the crossreaction between T felistome of the cat and immune forces of its owner, earlier infected by any of 3 T sp. inhabiting the man worldwide.The crossimmunity could be caused by common antigens of feline and human Ts, particularly if the related mammal organs of hosts are colonised.

As the structures of T antigens, mostly secreting proteinases,depend on composition of surrounding nutrients,especially on animal proteins,so some parts of antigens can be common in protozoa of the pet and owner.

In our case,the strong immune challenge after cutaneous inoculation of Ts or only antigens,could "spontaneously" clear the cervical infection,particularly as genital mucosal membrane has lost nutritious glycogen during menopausal estrogen fall.

From parasitologic viewpoint,pigmentation around parasite entry and connective tissue hyperplasia on the outskirts of host/pathogen contact,suggest the possible parasite involving.Her age (49) could also be included in the above concept.

Clinico-pathologic and epidemilogical effects of the close cat/man contact,both infected and sensitized with related protozoa should not be underrated,especially because these agents have strong immunoerosive potential and can be the vectors and even protectors of various bacteria and viruses,including HIV,during antibiotic cure.

Presented in part on 12th International Congress of Immunology held 2004 in Montreal, Canada.