METRONIDAZOLE (M) TRICHOMONIASIS (T) ERADICATION AS POSSIBLE POTENT IMMUNITY RESTORING PROCEDURE IN AIDS
Krvavac Sukrija; Rustembegovic A.
University and Medical Center,Women´s Health Institute Sarajevo, Yugoslavia (Now Bosnia and Herzegovina)
Duesberg´s firm conviction about nonviral cause (1) of AIDS is in complete accordance with recently exposed (2) AIDS conception of subepithelial T as the most frequent,but since now neglected initiator and/or supporter of immunosupression.
Regarding the existence of cross-immunity by all the three known trichomonal species (Trichomonas vag.,Tr.intestinalis and Tr.oralis),it seemed to us logically to suppose that,if the host get freed from the pressure of trichomonal antigens on its immune apparatus,it will be easier to resist to other antigens. Because of that, we have determined T/4T/8 by 7 patients with symptomatic genital T before and after M therapy.
As positive effect of M shouldn´t be attributed to repression of anaerobic bacterias, patients without noticeable focuses with such bacterias had been choosen.
An positive effect had been revealed, i.e. increasing of that indicator of immune status. Similar Positive effects of M on immune status had been noticed by experimental animals(3) but without date about eventual (intestinal) trichomoniasis of animals. Regarding frequent T, supra- or infra-epithelial locations (taking together all human species), as well as their very large antigenic repertoire, we think that those strong immunogenic agents can be at least partners to viruses in etiopathogenesis of AIDS.
Accordingly,and independently of possible dilemma what primary and what is secondary immunosuppressive ADS agent, authors think that careful use of M, with consequent T eradication,may have restoative effect on immune status of AIDS patients and risk groups.
1) Duesberg,P.: HIV is not cause of AIDS. Science, 29.July 1988,p.514,
2) Krvavac,S.:Trichomonas species as dominant immunopathogenic agent of AIDS. Ixth Eur. Immun.Meeting,Rome 14-19 IX 1988 p.23.
3) Shroit.I.G.et al.:Influence of metronidazole on the course of experimental anaerobic streptococcal pneumonia.J.Microb Epid Immunol 1986,4;21
PRESENTED On V International Conference on AIDS 4-9 June1989 in Canada,Montreal. Abstracts p.564, M.C.P.138