ROUND FORMS OF TRICHOMONAS SPECIES AS DOMINANT IMMUNOPATHOGENIC
 AGENT OF AIDS
                          -A NEGLECTED PARASITEMIA-

Krvavac Š., Women's Health Institute,71000 Sarajevo, Livanjska 40,
Yugoslavia (now Bosnia-Herzegovina)

All the three species of human trichomonads (Ts):Trichomonas
vaginalis,hominis and tenax are facultatively pathogenic but obligatory immunogenic,that
manifests by subclinical sensitization and stronger secondary than primary
pathogenicity.
The common antigen(s) in all species induce(s) crossed immunity so
explaining already noticed absonce of simultaneous established infections with more
species of Ts on their typical locations.
Along with immune responses,there are also similar pathological changes on
experimental animals caused by Ts of all species,which only in quantity differ
from one to another species or strain,varying according to degreeof pathogenic
potentials.Clinical symptoms depend on functional specificityof infected organs
and they are reflection of disfunctions caused by similar pathological changes.
Similar immune responses and pathological changes,as well as parallelismof
clinical symptoms,support the author's  attitude that it's about an unique
infective disease,disregarding which species of Ts it's about.Looking from that
point of wiev it's most expanded disease of humanity ans,according to authors
observations,shortliving parasitemiais not at all rare event.
Last 6 decades appeared more reports on trichomonemia,but this phenomenon
had never been explained nor its pathological consequences had been recognized.
It is known biological fact that more pigmented host have more expressed
natural mucous resistance that leads,by established infection,to the occurence of
more virulent ,mostly,tropical strains of Ts.Such strains by original hosts
cause only sensitization,but they along with simultanous action of other
antigens especially in nonphyiological circumstances (homosexuality,promiscuity,drugg
addiction,transfusion) cause more frequently the exhaustion of immune
apparatus in less pigmented,less resistant hosts.That relative overplus of
immunogenicity in tropical Ts erodes strongly the immunity in hosts with wicker,genetically
determined natural resistance and aleviates opportunistic infections such as
it is HIV,too!
After penetration throgh ectodermal barrier Ts enter lymph- and
hemo-circulation that resultsin maximal sensitization and extreme exhaustion of immune
capacity.
Deap penetration of Ts and strong sensitization are cause for strikingly rare
presence of Ts on mucous membranes,except probably on rectal by homosexuals
in AIDS patients. If lymph apparatus retains penetration of Ts,than
lymphadenopathy occurs,which is already noticed in genital trichomoniasis.
Congenital or peripartal infection,or only sensitization of fetus/newborn
with the most immunogenic vaginal Ts explains pediatric AIDS.
Fixing of the smears of blood and various secretions makes differenciation
of round Ts from leukocytes impossible,that results in fatal "mimicry".That
pseudomimicry of aflagellary Ts in examination of sperm is of greate importance
because of very frequent trichomonal infection of prostate (in blacks till 70%).
Like as for some other viruses Ts are also target of HIV infection and serve
as their vectors.That hyperparasitosis explains enigmatic HIV behaviour.


In this form presented on IXth European Immunology Meeting (EFIS),held in
Roma, Italy,September 14-17, 1988.ABSTRACTS P.:23. Full text published in Medical
Hypotheses 1992,vol.39,no 3,pp:225-8.